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Article

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.

Endocrinology - 1 Nov 1996

Lee K, Lanske B, Karaplis A C, Deeds J D, Kohno H, Nissenson R A, Kronenberg H M, Segre G V

Abstract excerpt

To test the hypothesis that PTH-related peptide (PTHrP) is a paracrine regulator of endochondral bone development, we localized PTHrP and its cognate receptor during normal skeletal development at both messenger RNA (mRNA) and protein levels and compared the growth plate phenotypes of PTHrP-deficient [(PTHrP(-/-)] mice to those of normal littermates [PTHrP(+/+]. PTHrP mRNA was expressed adjacent to uncavitated...

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Source

Identifiers

PMID: 8895385
DOI: 10.1210/endo.137.11.8895385

Genes

PTH

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.PMID 8895385Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.Semantic proximity Read ↗

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Semantic proximity Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Expression of bone-specific genes by hypertrophic chondrocytes: Implications of the complex functions of the hypertrophic chondrocyte during endochondral bone developmentSemantic proximity Read ↗

Parathyroid hormone-related protein is required for tooth eruption.Semantic proximity Read ↗

Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.Semantic proximity Read ↗

The CREB family of activators is required for endochondral bone development.Semantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse modelSemantic proximity Read ↗

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.Semantic proximity Read ↗

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