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Article

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.

Pediatric nephrology (Berlin, Germany) - 1 Jul 2000

Jüppner H

Abstract excerpt

Parathyroid hormone-related peptide (PTHrP), which frequently causes the humoral hypercalcemia of malignancy syndrome, is an autocrine/paracrine regulator of chondrocyte proliferation and differentiation that acts through the PTH/PTHrP receptor (PTH1R). PTHrP is generated in response to Indian hedgehog (Ihh), which mediates its actions through the membrane receptor patched, but interacts also with...

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Identifiers

PMID: 10912527
DOI: 10.1007/s004670000343

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.PMID 10912527Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

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The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

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Human diseases caused by homozygous PTH1R mutations.Semantic proximity Read ↗

A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.Semantic proximity Read ↗

Progression of Mineral Ion Abnormalities in Patients With Jansen Metaphyseal Chondrodysplasia.Semantic proximity Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.Semantic proximity Read ↗

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.Semantic proximity Read ↗

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