Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.

Bone - 1 Jan 2004

Amizuka Norio, Davidson David, Liu Hanlong, Valverde-Franco Gladys, Chai Sen, Maeda Takeyasu, Ozawa Hidehiro, Hammond Vicki, Ornitz David M, Goltzman David, Henderson Janet E

Abstract excerpt

Bone development is regulated by conserved signalling pathways that are linked to multifunctional growth factors and their high affinity receptors. Parathyroid hormone-related peptide (PTHrP) and fibroblast growth factor receptor 3 (FGFR3) have been shown to play pivotal, and sometimes complementary, roles in the replication, maturation and death of chondrocytes during endochondral bone formation. To gain further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type II
Share to Bone Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage

Share to Collagen Type X

Share to Growth Plate

Share to Parathyroid Hormone-Related Protein

Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Identifiers

PMID: 14751559
DOI: 10.1016/j.bone.2003.08.009

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development.PMID 14751559Read ↗

[Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways].Semantic proximity Read ↗

A Ser365->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasiaSemantic proximity Read ↗

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.Semantic proximity Read ↗

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.Semantic proximity Read ↗

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.Semantic proximity Read ↗

Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.Semantic proximity Read ↗

An activating Fgfr3 mutation affects trabecular bone formation via a paracrine mechanism during growth.Semantic proximity Read ↗

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.Semantic proximity Read ↗

Fibroblast growth factor receptor 3 is a negative regulator of bone growth.Semantic proximity Read ↗

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.Semantic proximity Read ↗

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.Semantic proximity Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.