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Article

Parathyroid hormone-related protein is required for tooth eruption.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Philbrick W M, Dreyer B E, Nakchbandi I A, Karaplis A C

Abstract excerpt

Parathyroid hormone (PTH)-related protein (PTHrP)-knockout mice die at birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation, whereas overexpression of PTHrP in the chondrocytes of transgenic mice produces a delay in chondrocyte maturation and endochondral ossification. Replacement of PTHrP expression in the chondrocytes of PTHrP-knockout...

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Identifiers

PMID: 9751753
DOI: 10.1073/pnas.95.20.11846
PMCID: PMC21728

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Parathyroid hormone-related protein is required for tooth eruption.PMID 9751753Read ↗

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Disturbed tooth development in parathyroid hormone-related protein (PTHrP)-gene knockout miceSemantic proximity Read ↗

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Semantic proximity Read ↗

Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction<sup>1</sup>Semantic proximity Read ↗

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.Semantic proximity Read ↗

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.Semantic proximity Read ↗

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Semantic proximity Read ↗

Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.Semantic proximity Read ↗

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