Asymmetric (deoxy dimer/azido-met dimer) hemoglobin hybrids dissociate within seconds.

doi:10.1006/jmbi.1999.2970

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Article

Asymmetric (deoxy dimer/azido-met dimer) hemoglobin hybrids dissociate within seconds.

Journal of molecular biology - 6 Aug 1999

Kiger L, Marden M C

Abstract excerpt

Double mixing stopped-flow experiments have been performed to study the stability of asymmetric hemoglobin (Hb) hybrids, consisting of a deoxy and a liganded dimer. The doubly liganded [deoxy/cyano-met] hybrid (species 21) was reported to have an enhanced stability, with tetramer to dimer dissociation requiring over 100 seconds, based on a method that required an incubation of over two days. However, kinetic...

Topics

Allosteric Regulation
Azides
Computer Simulation
Hemoglobins
Ligands
Mutation
Oxidation-Reduction
Protein Binding
Protein Conformation
Protein Denaturation
Protein Multimerization

Source

Open in PubMed

Identifiers

PMID: 10438617
DOI: 10.1006/jmbi.1999.2970

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