Article
Asymmetric (deoxy dimer/azido-met dimer) hemoglobin hybrids dissociate within seconds.
Journal of molecular biology - 6 Aug 1999
Kiger L, Marden M C
Abstract excerpt
Double mixing stopped-flow experiments have been performed to study the stability of asymmetric hemoglobin (Hb) hybrids, consisting of a deoxy and a liganded dimer. The doubly liganded [deoxy/cyano-met] hybrid (species 21) was reported to have an enhanced stability, with tetramer to dimer dissociation requiring over 100 seconds, based on a method that required an incubation of over two days. However, kinetic...
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