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Article

Quaternary structure of carbonmonoxyhemoglobins in solution: structural changes induced by the allosteric effector inositol hexaphosphate.

Biochemistry - 25 Apr 2006

Gong Qingguo, Simplaceanu Virgil, Lukin Jonathan A, Giovannelli Janel L, Ho Nancy T, Ho Chien

Abstract excerpt

We have applied the residual dipolar coupling (RDC) method to investigate the solution quaternary structures of (2)H- and (15)N-labeled human normal adult recombinant hemoglobin (rHb A) and a low-oxygen-affinity mutant recombinant hemoglobin, rHb(alpha96Val-->Trp), both in the carbonmonoxy form, in the absence and presence of an allosteric effector, inositol hexaphosphate (IHP), using a stretched polyacrylamide...

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PMID: 16618103
DOI: 10.1021/bi052424h

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