Article
Recombinant hemoglobins as artificial oxygen carriers.
Artificial cells, blood substitutes, and immobilization biotechnology - 1 Jan 2007
Fronticelli Clara, Koehler Raymond C, Brinigar William S
Abstract excerpt
This paper describes the approaches we have taken to construct a) mutant hemoglobins with different oxygen affinities, and b) mutant hemoglobins and myoglobins that polymerize to high molecular weight aggregates in an effort to prevent extravasation and the associated vasoactivity. In vivo testing indicates that exchange transfusion of polymeric hemoglobins in mice does not result in vasoactivity and that...
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