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Article

Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids.

The Journal of biological chemistry - 19 Apr 2002

Li Xianfeng, Briehl Robin W, Bookchin Robert M, Josephs Robert, Wei Baoyang, Manning James M, Ferrone Frank A

Abstract excerpt

As part of an effort to understand the interactions in HbS polymerization, we have produced and studied a recombinant triple mutant, D6A(alpha)/D75Y(alpha)/E121R(beta), and a quadruple mutant comprising the preceding mutation plus the natural genetic mutation of sickle hemoglobin, E6V(beta). These recombinant hemoglobins expressed in yeast were extensively characterized, and their structure and oxygen binding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11782463
DOI: 10.1074/jbc.M108149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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