Article
Functional properties of human hemoglobins synthesized from recombinant mutant beta-globins.
Biochemistry - 15 Sept 1992
Doyle M L, Lew G, De Young A, Kwiatkowski L, Wierzba A, Noble R W, Ackers G K
Abstract excerpt
The previous and following articles in this issue describe the recombinant synthesis of three mutant beta-globins (beta 1 Val----Ala, beta 1 Val----Met, and the addition mutation beta 1 + Met), their assembly with heme and natural alpha chains into alpha 2 beta 2 tetramers, and their X-ray crystallographic structures. Here we have measured the equilibrium and kinetic allosteric properties of these hemoglobins....
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