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Article

Recombinant hemoglobin betaG83C-F41Y.

The FEBS journal - 1 Jan 2006

Vasseur-Godbillon Corinne, Sahu Sarata C, Domingues Elisa, Fablet Christophe, Giovannelli Janel L, Tam Tsuey Chyi, Ho Nancy T, Ho Chien, Marden Michael C, Baudin-Creuza Véronique

Abstract excerpt

We have engineered a stable octameric hemoglobin (Hb) of molecular mass 129 kDa, a dimer of recombinant hemoglobin (rHb betaG83C-F41Y) tetramers joined by disulfide bonds at the beta83 position. One of the major problems with oxygen carriers based on acellular hemoglobin solutions is vasoactivity, a limitation which may be overcome by increasing the molecular size of the carrier. The oxygen equilibrium curves...

Topics

Dimerization
Dose-Response Relationship, Drug
Haptoglobins
Hemoglobins
Hemoglobins, Abnormal
Humans
Hydrogen-Ion Concentration
Kinetics
Ligands
Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxidation-Reduction

Oxygen

Protein Engineering

Protein Structure, Secondary

Recombinant Proteins

Temperature

Time Factors

Source

Identifiers

PMID: 16367763
DOI: 10.1111/j.1742-4658.2005.05063.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16367763-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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