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Article

COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000.

Acta crystallographica. Section D, Biological crystallography - 1 May 2005

Patskovska Larysa N, Patskovsky Yury V, Almo Steven C, Hirsch Rhoda Elison

Abstract excerpt

Human hemoglobin binds oxygen cooperatively and functions as a tetramer composed of two identical alphabeta heterodimers. While human hemoglobin is the best characterized allosteric protein, the quaternary R (oxygenated or liganded) to T (deoxygenated) structural transition remains controversial. The R2 state has been postulated to represent either an intermediate or final quaternary state elicited by ligand...

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Identifiers

PMID: 15858266
DOI: 10.1107/S0907444905004622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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