Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000.

Acta crystallographica. Section D, Biological crystallography - 1 May 2005

Patskovska Larysa N, Patskovsky Yury V, Almo Steven C, Hirsch Rhoda Elison

Abstract excerpt

Human hemoglobin binds oxygen cooperatively and functions as a tetramer composed of two identical alphabeta heterodimers. While human hemoglobin is the best characterized allosteric protein, the quaternary R (oxygenated or liganded) to T (deoxygenated) structural transition remains controversial. The R2 state has been postulated to represent either an intermediate or final quaternary state elicited by ligand...

Topics

Carboxyhemoglobin
Chemical Phenomena
Chemistry, Physical
Crystallization
Crystallography, X-Ray
Hemoglobin, Sickle
Humans
Hydrogen-Ion Concentration
Indicators and Reagents
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polyethylene Glycols

Solubility

Source

Identifiers

PMID: 15858266
DOI: 10.1107/S0907444905004622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15858266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000.PMID 15858266Read ↗

The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix.Semantic proximity Read ↗

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility.Semantic proximity Read ↗

Recombinant hemoglobins with low oxygen affinity and high cooperativity.Semantic proximity Read ↗

Beta7E-beta132K salt bridge and sickle haemoglobin stability and conformation.Semantic proximity Read ↗

Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cellSemantic proximity Read ↗

Hb Vila Real [beta36(C2)Pro-->His]: a newly discovered high oxygen affinity variant.Semantic proximity Read ↗

Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation.Semantic proximity Read ↗

Crystal structures of HbA2 and HbE and modeling of hemoglobin delta 4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb.Semantic proximity Read ↗

Structure of fully liganded Hb ζ2β2s trapped in a tense conformation.Semantic proximity Read ↗

Atomistic Simulations of Heme Dissociation Pathways in Human Methemoglobins Reveal Hidden Intermediates.Semantic proximity Read ↗

Structure-Function Relations of Human HemoglobinsSemantic proximity Read ↗

Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.