Article
Molecular code for cooperativity in hemoglobin.
Science (New York, N.Y.) - 3 Jan 1992
Ackers G K, Doyle M L, Myers D, Daugherty M A
Abstract excerpt
Although tetrameric hemoglobin has been studied extensively as a prototype for understanding mechanisms of allosteric regulation, the functional and structural properties of its eight intermediate ligation forms have remained elusive. Recent experiments on the energetics of cooperativity of these intermediates, along with assignments of their quaternary structures, have revealed that the allosteric mechanism is...
Topics
- Allosteric Regulation
- Calorimetry
- Circular Dichroism
- Hemoglobins
- Kinetics
- Ligands
- Macromolecular Substances
- Models, Molecular
- Mutation
- Oxyhemoglobins
- Protein Conformation
- Thermodynamics