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Article

Oxygen equilibrium and EPR studies on alpha1beta1 hemoglobin dimer.

Journal of biochemistry - 1 Nov 2004

Venkatesh Balan, Miyazaki Gentaro, Imai Kiyohiro, Morimoto Hideki, Hori Hiroshi

Abstract excerpt

We undertook this project to clarify whether hemoglobin (Hb) dimers have a high affinity for oxygen and cooperativity. For this, we prepared stable Hb dimers by introducing the mutation Trp-->Glu at beta37 using our Escherichia coli expression system at the alpha1beta2 interface of Hb, and analyzed their molecular properties. The mutant hybrid Hbs with a single oxygen binding site were prepared by substituting...

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PMID: 15632298
DOI: 10.1093/jb/mvh166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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