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Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition.

Experimental cell research - 1 Aug 1999

Anghileri P, Branduardi P, Sternieri F, Monti P, Visintin R, Bevilacqua A, Alberghina L, Martegani E, Baroni M D

Abstract excerpt

Cell cycle progression of somatic cells depends on net mass accumulation. In Saccharomyces cerevisiae the cAMP-dependent kinases (PKAs) promote cytoplasmic growth and modulate the growth-regulated mechanism triggering the begin of DNA synthesis. By altering the cAMP signal in budding yeast cells we show here that mitotic events can also depend on growth. In fact, the hyperactivation of PKAs permanently inhibited...

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PMID: 10413604
DOI: 10.1006/excr.1999.4531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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