Article
cAMP inhibits bud growth in a yeast strain compromised for Ca2+ influx into the Golgi.
Molecular & general genetics : MGG - 19 Jul 1996
Hartley A D, Bogaerts S, Garrett S
Abstract excerpt
Biochemical and physiological studies have implicated cAMP and cAMP-dependent protein kinase (PKA) in a plethora of essential cellular processes. Here we show that yeast cells partially depleted of PKA activity (due to a tpkw mutation) and bearing a lesion in a Golgi-localized Ca2+ pump (Pmr1), arrest division with a small bud. The bud morphology of the arrested tpk1w pmr1 mutant cells is characteristic of cells...
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