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Article

Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Sept 1999

Yanagida M, Yamashita Y M, Tatebe H, Ishii K, Kumada K, Nakaseko Y

Abstract excerpt

Ubiquitin-mediated proteolysis is fundamental to cell cycle progression. In the fission yeast Schizosaccharomyces pombe, a mitotic cyclin (Cdc13), a key cell cycle regulator, is degraded for exiting mitosis, while Cut2 has to be destroyed for the onset of sister chromatid separation in anaphase. Ubiquitination of these proteins requires the special destruction box (DB) sequences locating in their N-termini and...

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Identifiers

PMID: 10582241
DOI: 10.1098/rstb.1999.0499
PMCID: PMC1692673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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