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Article

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.

Genes & development - 1 Aug 1999

Tinker-Kulberg R L, Morgan D O

Abstract excerpt

The separation of sister chromatids in anaphase is followed by spindle disassembly and cytokinesis. These events are governed by the anaphase-promoting complex (APC), which triggers the ubiquitin-dependent proteolysis of key regulatory proteins: anaphase requires the destruction of the anaphase inhibitor Pds1, whereas mitotic exit requires the destruction of mitotic cyclins and the inactivation of Cdk1. We find...

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Identifiers

PMID: 10444592
DOI: 10.1101/gad.13.15.1936
PMCID: PMC316917

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.PMID 10444592Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

‘… The End of the Beginning’: Cdk1 Thresholds and Exit from MitosisSemantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.Semantic proximity Read ↗

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Semantic proximity Read ↗

Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin.Semantic proximity Read ↗

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