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Article

‘… The End of the Beginning’: Cdk1 Thresholds and Exit from Mitosis

15 Jun 2007

Abstract excerpt

Exit from mitosis requires the proteolytic degradation of mitotic cyclins, which is instigated by the APC/C ubiquitin ligase. The coincidence of mitotic cyclin B1 degradation with the onset of anaphase intuitively suggested a requirement of cyclin degradation for sister chromatid separation. While this hypothesis has originally been refuted, evidence that cyclin B1 degradation is required for anaphase during...

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Identifiers

PMID: 17581279
DOI: 10.4161/cc.6.12.4361

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