Article
Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection.
European journal of immunology - 1 Feb 2001
Santos-Lima E C, Vasconcellos R, Reina-San-Martín B, Fesel C, Cordeiro-Da-Silva A, Berneman A, Cosson A, Coutinho A, Minoprio P
Abstract excerpt
The Xid mutation predominantly affects the development of B cells and consequently the levels and composition of natural antibodies in sera. In contrast to the congenic and susceptible BALB/c strain, immunodeficient BALB.Xid mice display a resistant phenotype both to acute Trypanosoma cruzi infection and to the development of severe cardiopathy. Because natural antibodies are known to be basically self-antigen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.