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Article

Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice.

International journal of immunopharmacology - 1 Jun 1995

Solbach W, Asmuss P A, Zimmermann S, Humborg C, Röllinghoff M

Abstract excerpt

Leflunomide has been reported as an immunomodulating agent which acts on a variety of cells including T- and B-lymphocytes. CD4+ T-lymphocytes are essential for the type of disease that develops after infection with the protozoan parasite Leishmania major. A variety of immunological interventions has been shown to modulate disease development. Therefore, the effect of leflunomide on the development of...

Topics

Animals
Antiparasitic Agents
Antiprotozoal Agents
Female
Genetic Predisposition to Disease
Immunity, Innate
Isoxazoles
Leflunomide
Leishmania major
Leishmaniasis, Cutaneous
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Source

Identifiers

PMID: 7499024
DOI: 10.1016/0192-0561(95)00028-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7499024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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