Article
Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008
Ronet Catherine, Voigt Heike, Himmelrich Hayo, Doucey Marie-Agnès, Hauyon-La Torre Yazmin, Revaz-Breton Mélanie, Tacchini-Cottier Fabienne, Bron Claude, Louis Jacques, Launois Pascal
Abstract excerpt
B lymphocytes are considered to play a minimal role in host defense against Leishmania major. In this study, the contribution of B cells to susceptibility to infection with different strains of L. major was investigated in BALB/c mice lacking mature B cells due to the disruption of the IgM transmembrane domain (microMT). Whereas BALB/c microMT remained susceptible to infection with L. major IR173 and IR75, they...
Topics
- Adoptive Transfer
- Animals
- Antibodies, Protozoan
- Antigen-Presenting Cells
- B-Lymphocytes
- Cell Differentiation
- Cells, Cultured
- Disease Susceptibility
- Immunity, Innate
- Leishmania major
- Leishmaniasis, Cutaneous
- Mice