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Article

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1 Sept 1996

Abstract excerpt

Mice with a genetically engineered deficiency for either IL-4 or IFN-gamma R1 (single mutants), and IL-4/IFN-gamma R1 (double mutants) on the Balb/c and 129Sv background were used to study the course of infection with Leishmania major. In contrast to genetically resistant 129Sv wildtype mice, IL-4/IFN-gamma R1 double mutant mice developed fetal disease with parasite dissemination to visceral organs similar to...

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PMID: 9064329
DOI: 10.1084/jem.184.3.1127

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