Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Regulation of Immunity to Leishmania Major

1 Apr 1995

Abstract excerpt

Experimental infection with the intracellular protozoan Leishmania major constitutes a particularly versatile model for assessing the role of CD4+ subset development in the host response to infectious disease. The association of Th1 development with control of infection, and of Th2 cell development with progressive disease, has been well established. The capacity to manipulate the outcome, using distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Research on Leishmaniasis Studies
Share to Toxin Mechanisms and Immunotoxins
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7612219
DOI: 10.1146/annurev.iy.13.040195.001055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Regulation of Immunity to Leishmania MajorPMID 7612219Read ↗

Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.Semantic proximity Read ↗

The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds.Semantic proximity Read ↗

The fate and persistence of Leishmania major in mice of different genetic backgrounds: an example of exploitation of the immune system by intracellular parasites.Semantic proximity Read ↗

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.Semantic proximity Read ↗

Polarized helper-T-cell responses against Leishmania major in the absence of B cells.Semantic proximity Read ↗

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.Semantic proximity Read ↗

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.Semantic proximity Read ↗

The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice.Semantic proximity Read ↗

Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependentSemantic proximity Read ↗

In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive DiseaseSemantic proximity Read ↗

IL-4-deficient Balb/c mice resist infection with Leishmania major.Semantic proximity Read ↗

The immune response to Plasmodium chabaudi malaria in interleukin‐4‐deficient miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.