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Article

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 1999

Moran J L, Siegel D, Ross D

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. A polymorphism in NQO1, a C609T substitution, has been identified, and individuals homozygous for this change (T/T) have no detectable NQO1. Exposed workers with a T/T genotype have an increased risk of benzene hematotoxicity. This finding suggests NQO1 is...

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Identifiers

PMID: 10393963
DOI: 10.1073/pnas.96.14.8150
PMCID: PMC22203

Genes

NQO1

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.PMID 10393963Read ↗

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Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity.Semantic proximity Read ↗

Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.Semantic proximity Read ↗

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