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Article

GSTM1, GSTT1, and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes.

Environmental and molecular mutagenesis - 1 Jan 2004

Silva Maria do Céu, Gaspar Jorge, Duarte Silva Isabel, Faber Ana, Rueff José

Abstract excerpt

Hydroquinone is a myelotoxin that is found in many foods and is also formed through the metabolism of benzene. Human exposure to benzene is associated with the development of myelodysplastic syndrome and acute myelogenous leukemia. Hydroquinone is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. Glutathione...

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Source

Identifiers

PMID: 15141365
DOI: 10.1002/em.20015

Genes

GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GSTM1, GSTT1, and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes.PMID 15141365Read ↗

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.Semantic proximity Read ↗

GSTM1, GSTT1, and GSTP1 polymorphism in north Indian population and its influence on the hydroquinone-induced in vitro genotoxicity.Semantic proximity Read ↗

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.Semantic proximity Read ↗

Comparison of the repair of DNA damage induced by the benzene metabolites hydroquinone and p-benzoquinone: a role for hydroquinone in benzene genotoxicity.Semantic proximity Read ↗

Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.Semantic proximity Read ↗

Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1.Semantic proximity Read ↗

Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.Semantic proximity Read ↗

Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.Semantic proximity Read ↗

The influence of GSTM1 null genotype on susceptibility to in vitro oxidative stress.Semantic proximity Read ↗

Hydroquinone: An Evaluation of the Human Risks from its Carcinogenic and Mutagenic PropertiesSemantic proximity Read ↗

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