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Article

Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2007

Chen Y, Li G, Yin S, Xu J, Ji Z, Xiu X, Liu L, Ma D

Abstract excerpt

Benzene is a recognized haematotoxin and leukaemogen, but its mechanism of action and the role of genetic susceptibility are still unclear. Cytochrome P450 2E1 (CYP2E1) and myeloperoxidase (MPO) are involved in benzene activation; and NAD (P)H:quinine oxidoreductase 1 (NQO1), glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) participate in benzene detoxification. The common,...

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Source

Identifiers

PMID: 17178637
DOI: 10.1080/00498250601001662

Genes

GSTT1
NQO1
GSTM1
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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