Article

Biological and Clinical Significance of Polymorphisms in NAD(P)H: Quinone Oxidoreductase 1 (NQO1).

2004-03-01

Abstract excerpt

NQO1 (NAD(P)H:quinone oxidoreductase-1) is a cytosolic flavoprotein that catalyses the two-electron reduction of endogenous and environmental quinones. NQO1 plays a prominent role in protecting cells from the toxic effects of quinones, oxidative stress and more recently, the stabilisation of p53. Paradoxically, NQO1 is a target for anti-cancer drug development as reduction of certain quinones can generate cytotoxi...

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Literature Corpus work: e0dbce86-8e97-5bcc-b46b-77a12ed9a49d
DOI: 10.2174/1570160043476079

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