Article
Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.
Journal of toxicology and environmental health. Part A - 1 Jan 2010
Zhang Juan, Yin Lihong, Liang Geyu, Liu Ran, Pu Yuepu
Abstract excerpt
Single-nucleotide polymorphisms (SNP) in genes coding metabolizing enzymes modulate gene functions and cellular toxicity in response to chemicals. Quinone oxidoreductase 1 (NQO1) is an important detoxification enzyme involved in the catabolism of 1,4-benzoquinone (1,4-BQ), a benzene metabolite believed to be associated with bone-marrow toxicity and leukemia. Gene function was evaluated in immortalized human B...
Topics
- Adolescent
- Adult
- B-Lymphocytes
- Benzene
- Benzoquinones
- Cell Line
- Cell Proliferation
- China
- DNA Damage
- DNA Fingerprinting
- Enzyme Induction
- Female
- Humans
- Male
- Middle Aged