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Article

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000

Nebert Daniel W, Roe Amy L, Vandale Susan E, Bingham Eula, Oakley Gregory G

Abstract excerpt

NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two- or four-electron reduction of numerous endogenous and environmental quinones (e.g., the vitamin E alpha-tocopherol quinone, menadione, benzene quinones). In laboratory animals treated with various environmental chemicals, inhibition of NQO1 metabolism has long been known to increase the risk of toxicity or cancer. Currently, there are 22 reported...

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Source

Identifiers

PMID: 11882782
DOI: 10.1097/00125817-200203000-00003

Genes

NQO1
EPHX1
GSTM1
GSTT1
MPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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