Article
NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000
Nebert Daniel W, Roe Amy L, Vandale Susan E, Bingham Eula, Oakley Gregory G
Abstract excerpt
NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two- or four-electron reduction of numerous endogenous and environmental quinones (e.g., the vitamin E alpha-tocopherol quinone, menadione, benzene quinones). In laboratory animals treated with various environmental chemicals, inhibition of NQO1...
Topics
- Alleles
- Animals
- Benzene
- Bone Marrow Diseases
- Environmental Exposure
- Gene Frequency
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- NAD(P)H Dehydrogenase (Quinone)
- Point Mutation
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length