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Article

Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1.

Cancer research - 1 Mar 2003

Bauer Alison K, Faiola Brenda, Abernethy Diane J, Marchan Rosemarie, Pluta Linda J, Wong Vicki A, Roberts Kay, Jaiswal Anil K, Gonzalez Frank J, Butterworth Byron E, Borghoff Susan, Parkinson Horace, Everitt Jeffrey, Recio Leslie

Abstract excerpt

Enzymes that activate and detoxify benzene are likely genetic determinants of benzene-induced toxicity.NAD(P)H: quinone oxidoreductase-1 (NQO1) detoxifies benzoquinones, proposed toxic metabolites of benzene. NQO1 deficiency in humans is associated with an increased risk of leukemia, specifically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2E1

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Share to NAD(P)H Dehydrogenase (Quinone)

Source

Identifiers

PMID: 12615705

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12615705-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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