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Article

A role for a replicator dominance mechanism in silencing.

The EMBO journal - 1 Jul 1999

Palacios DeBeer M A, Fox C A

Abstract excerpt

The role of the natural HMR-E silencer in modulating replication initiation and silencing by the origin recognition complex (ORC) was examined. When natural HMR-E was the only silencer controlling HMR, the silencer's ORC-binding site (ACS) was dispensable for replication initiation but essential for silencing, indicating that a non-silencer chromosomal replicator(s) existed in close proximity to the silencer....

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Share to Regulatory Sequences, Nucleic Acid
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 10393196
DOI: 10.1093/emboj/18.13.3808
PMCID: PMC1171458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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