Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Separation of origin recognition complex functions by cross-species complementation.

Science (New York, N.Y.) - 8 Dec 1995

Ehrenhofer-Murray A E, Gossen M, Pak D T, Botchan M R, Rine J

Abstract excerpt

Transcriptional silencing at the HMRa locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1 strain, which is defective for replication and silencing, complemented the silencing defect but not the replication defect; this result indicated that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to DNA-Binding Proteins
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, Fungal

Share to Genetic Complementation Test

Share to Mutation

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 7502078
DOI: 10.1126/science.270.5242.1671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Separation of origin recognition complex functions by cross-species complementation.PMID 7502078Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Two compound replication origins in Saccharomyces cerevisiae contain redundant origin recognition complex binding sites.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Functional analysis of an Orc6 mutant in Drosophila.Semantic proximity Read ↗

Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.