ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.

doi:10.1016/0092-8674(95)90528-6

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Article

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.

Cell - 2 Jun 1995

Liang C, Weinreich M, Stillman B

Abstract excerpt

The origin recognition complex (ORC) binds replicators in the yeast S. cerevisiae in a manner consistent with it being an initiator protein for DNA replication. Two-dimensional (2D) gel techniques were used to examine directly initiation of chromosomal DNA replication in temperature-sensitive orc mutants. Unlike in wild-type cells, in orc2-1 and orc5-1 mutant cells, only a subset of replicators formed active...

Topics

Cell Cycle Proteins
Chromosomes, Fungal
Cloning, Molecular
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Electrophoresis, Gel, Two-Dimensional
Genes, Lethal
Genome, Fungal
Mutation
Origin Recognition Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Recombinant Fusion Proteins

Replication Origin

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 7774008
DOI: 10.1016/0092-8674(95)90528-6

Genes

CDC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7774008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.PMID 7774008Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Semantic proximity Read ↗

Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

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