Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.

Cell - 2 Jun 1995

Liang C, Weinreich M, Stillman B

Abstract excerpt

The origin recognition complex (ORC) binds replicators in the yeast S. cerevisiae in a manner consistent with it being an initiator protein for DNA replication. Two-dimensional (2D) gel techniques were used to examine directly initiation of chromosomal DNA replication in temperature-sensitive orc mutants. Unlike in wild-type cells, in orc2-1 and orc5-1 mutant cells, only a subset of replicators formed active...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to DNA-Binding Proteins
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Binding

Share to Recombinant Fusion Proteins

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 7774008
DOI: 10.1016/0092-8674(95)90528-6

Genes

CDC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome.PMID 7774008Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Semantic proximity Read ↗

Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.