Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast.

Nucleic acids research - 1 Jan 2006

Bolon Yung-Tsi, Bielinsky Anja-Katrin

Abstract excerpt

In the quest to define autonomously replicating sequences (ARSs) in eukaryotic cells, an ARS consensus sequence (ACS) has emerged for budding yeast. This ACS is recognized by the replication initiator, the origin recognition complex (ORC). However, not every match to the ACS constitutes a replication origin. Here, we investigated the requirements for ORC binding to origins that carry multiple, redundant ACSs,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Consensus Sequence
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Origin Recognition Complex

Share to Replication Origin

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16984967
DOI: 10.1093/nar/gkl661
PMCID: PMC1635292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast.PMID 16984967Read ↗

Two compound replication origins in Saccharomyces cerevisiae contain redundant origin recognition complex binding sites.Semantic proximity Read ↗

High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.Semantic proximity Read ↗

Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences.Semantic proximity Read ↗

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Humanizing the yeast origin recognition complex.Semantic proximity Read ↗

Evolution of DNA replication origin specification and gene silencing mechanisms.Semantic proximity Read ↗

A yeast chromosomal origin of DNA replication defined by multiple functional elements.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Eucaryotic replication origin binding proteins.Semantic proximity Read ↗

Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III.Semantic proximity Read ↗

An autonomously replicating sequence for use in a wide range of budding yeasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.