Article
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.
Development (Cambridge, England) - 1 Aug 1999
Thomas J H, Horvitz H R
Abstract excerpt
The Caenorhabditis elegans gene lin-36 acts to antagonize Ras-mediated vulval induction in a pathway that includes genes with products similar to the mammalian retinoblastoma (Rb) protein and the Rb-binding protein p48. We report that lin-36 encodes a novel protein of 962 amino acids. We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the lin-36 pathway is...
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