Article
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Cell - 23 Dec 1998
Lu X, Horvitz H R
Abstract excerpt
The Ras signaling pathway for vulval induction in Caenorhabditis elegans is antagonized by the activity of the synthetic multivulva (synMuv) genes, which define two functionally redundant pathways. We have characterized two genes in one of these pathways. lin-35 encodes a protein similar to the t...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Carrier Proteins
- Cell Line
- Cell Lineage
- Cloning, Molecular
- Embryonic Induction
- Epistasis, Genetic
- Female
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Histone Deacetylases
- Humans
- Models, Genetic
- Molecular Sequence Data
- Mutation