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Article

The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway.

Genetics - 1 Feb 2006

Goldstein Jessica L, Glossip Danielle, Nayak Sudhir, Kornfeld Kerry

Abstract excerpt

Ras-mediated signaling is necessary for the induction of vulval cell fates during Caenorhabditis elegans development. We identified cgr-1 by screening for suppressors of the ectopic vulval cell fates caused by a gain-of-function mutation of the let-60 ras gene. Analysis of two cgr-1 loss-of-function mutations indicates that cgr-1 positively regulates induction of vulval cell fates. cgr-1 is likely to function at...

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Identifiers

PMID: 16219793
DOI: 10.1534/genetics.104.035550
PMCID: PMC1456255

Genes

TRIO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway.PMID 16219793Read ↗

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.Semantic proximity Read ↗

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