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Article

sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.

Developmental biology - 15 Aug 2000

Grant K, Hanna-Rose W, Han M

Abstract excerpt

Vulval cell-fate determination in Caenorhabditis elegans requires the action of numerous gene products, including components of the Ras/Raf/MAPK signaling cascade and the hox gene lin-39. sem-4 encodes a zinc finger protein with previously characterized roles in fate specification of sex myoblast...

Topics

Alleles
Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Lineage
DNA Primers
DNA-Binding Proteins
Female
Gene Expression Regulation, Developmental
Helminth Proteins
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Vulva

Source

Identifiers

PMID: 10926783
DOI: 10.1006/dbio.2000.9774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10926783-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.PMID 10926783Read ↗

The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling.Semantic proximity Read ↗

The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.Semantic proximity Read ↗

The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.Semantic proximity Read ↗

Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein.Semantic proximity Read ↗

Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development.Semantic proximity Read ↗

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.Semantic proximity Read ↗

Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.Semantic proximity Read ↗

sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

The Pristionchus HOX gene Ppa-lin-39 inhibits programmed cell death to specify the vulva equivalence group and is not required during vulval induction.Semantic proximity Read ↗

LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion.Semantic proximity Read ↗

Characterization of seven genes affecting Caenorhabditis elegans hindgut development.Semantic proximity Read ↗

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