C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

doi:10.1038/363133a0

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Article

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

Nature - 13 May 1993

Han M, Golden A, Han Y, Sternberg P W

Abstract excerpt

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf g...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Differentiation
Cloning, Molecular
DNA
Female
Helminth Proteins
Humans
Male
Molecular Sequence Data
Mutation
Protein Serine-Threonine Kinases
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf

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Open in PubMed

Identifiers

PMID: 8483497
DOI: 10.1038/363133a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8483497-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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