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Article

lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans.

Development (Cambridge, England) - 1 Jul 2003

Fay David S, Large Edward, Han Min, Darland Monica

Abstract excerpt

The retinoblastoma gene product has been implicated in the regulation of multiple cellular and developmental processes, including a well-defined role in the control of cell cycle progression. The Caenorhabditis elegans retinoblastoma protein homolog, LIN-35, is also a key regulator of cell cycle entry and, as shown by studies of synthetic multivulval genes, plays an important role in the determination of vulval...

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PMID: 12783801
DOI: 10.1242/dev.00561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans.PMID 12783801Read ↗

New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.Semantic proximity Read ↗

Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.Semantic proximity Read ↗

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Semantic proximity Read ↗

The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.Semantic proximity Read ↗

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.Semantic proximity Read ↗

lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

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