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Article

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.

Development (Cambridge, England) - 1 Aug 1999

Hamada Y, Kadokawa Y, Okabe M, Ikawa M, Coleman J R, Tsujimoto Y

Abstract excerpt

Notch family genes encode transmembrane proteins involved in cell-fate determination. Using gene targeting procedures, we disrupted the mouse Notch2 gene by replacing all but one of the ankyrin repeat sequences in the cytoplasmic domain with the E. coli (beta)-galactosidase gene. The mutant Notch2 gene encodes a 380 kDa Notch2-(beta)-gal fusion protein with (beta)-galactosidase activity. Notch2 homozygous mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10393120
DOI: 10.1242/dev.126.15.3415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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