Article
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Development (Cambridge, England) - 1 Jun 1998
Sussel L, Kalamaras J, Hartigan-O'Connor D J, Meneses J J, Pedersen R A, Rubenstein J L, German M S
Abstract excerpt
The endocrine pancreas is organized into clusters of cells called islets of Langerhans comprising four well-defined cell types: alpha beta, delta and PP cells. While recent genetic studies indicate that islet development depends on the function of an integrated network of transcription factors, the specific roles of these factors in early cell-type specification and differentiation remain elusive. Nkx2.2 is a...
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