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Article

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.

Development (Cambridge, England) - 1 Feb 2014

Hagelkruys Astrid, Lagger Sabine, Krahmer Julia, Leopoldi Alexandra, Artaker Matthias, Pusch Oliver, Zezula Jürgen, Weissmann Simon, Xie Yunli, Schöfer Christian, Schlederer Michaela, Brosch Gerald, Matthias Patrick, Selfridge Jim, Lassmann Hans, Knoblich Jürgen A, Seiser Christian

Abstract excerpt

The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure and gene expression, thereby controlling important developmental processes. In the mouse brain, HDAC1 and HDAC2 exhibit different developmental stage- and lineage-specific expression patterns. To examine the individual contribution of these deacetylases during brain development, we deleted different combinations of Hdac1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24449838
DOI: 10.1242/dev.100487
PMCID: PMC4773893

Genes

HDAC2
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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