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Article

Aebp2 as an Epigenetic Regulator for Neural Crest Cells

19 Sept 2011

Abstract excerpt

Aebp2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2). We generated a mutant mouse line disrupting the transcription of Aebp2 to investigate its in vivo roles. Aebp2-mutant homozygotes were embryonic lethal while heterozygotes survived to adulthood with fertility. In developing mouse embryos, Aebp2 is expressed mainly within cells of neural crest origin. In addition, many...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21949878
DOI: 10.1371/journal.pone.0025174

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