Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Experimental cell research - 1 Oct 2009

Nornes Svanhild, Newman Morgan, Wells Simon, Verdile Giuseppe, Martins Ralph N, Lardelli Michael

Abstract excerpt

Presenilin1 (PSEN1) and presenilin2 (PSEN2) are involved in the processing of type-1 transmembrane proteins including the amyloid precursor protein (APP), Notch and several others. PSEN1 has been shown to be crucial for proteolytic cleavage of Notch in developing animal embryos. Mouse embryos lacking Psen1 function show disturbed neurogenesis and somite formation, resembling Notch pathway mutants. However, loss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Morphogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

Share to Presenilin-1

Share to Presenilin-2

Share to Receptor, Notch1

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 19563801
DOI: 10.1016/j.yexcr.2009.06.023

Genes

PSEN1
APP
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.PMID 19563801Read ↗

Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes.Semantic proximity Read ↗

Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene psen2.Semantic proximity Read ↗

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryosSemantic proximity Read ↗

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.Semantic proximity Read ↗

Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.Semantic proximity Read ↗

Transcriptome analysis indicates dominant effects on ribosome and mitochondrial function of a premature termination codon mutation in the zebrafish gene <i>psen2</i>Semantic proximity Read ↗

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.Semantic proximity Read ↗

Identification and characterization of presenilin-independent Notch signaling.Semantic proximity Read ↗

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine TissuesSemantic proximity Read ↗

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.