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Article

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

2 Jul 1999

Abstract excerpt

An estimated 170 million persons worldwide are infected with hepatitis C virus (HCV), a major cause of chronic liver disease. Despite increasing knowledge of genome structure and individual viral proteins, studies on virus replication and pathogenesis have been hampered by the lack of reliable and efficient cell culture systems. A full-length consensus genome was cloned from viral RNA isolated from an infected...

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PMID: 10390360
DOI: 10.1126/science.285.5424.110

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