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Article

Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture.

Journal of virology - 1 Mar 2003

Blight Keril J, McKeating Jane A, Marcotrigiano Joseph, Rice Charles M

Abstract excerpt

Hepatitis C virus (HCV) genotype 1 (subtypes 1a and 1b) is responsible for the majority of treatment-resistant liver disease worldwide. Thus far, efficient HCV RNA replication has been observed only for subgenomic and full-length RNAs derived from genotype 1b isolates. Here, we report the establishment of efficient RNA replication systems for genotype 1a strain H77. Replication of subgenomic and full-length H77...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Viral

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Source

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Identifiers

PMID: 12584342
DOI: 10.1128/jvi.77.5.3181-3190.2003
PMCID: PMC149761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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