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Hepatitis C Virus Subgenomic Replicons in the Human Embryonic Kidney 293 Cell Line

11 Dec 2003

Abstract excerpt

Hepatitis C virus (HCV) infects liver cells and its replication in other cells is incompletely defined. Human hepatoma Huh-7 cells harboring subgenomic HCV replicons were used in somatic cell fusion experiments with human embryonic kidney 293 cells as a means of examining the permissiveness of 293 cells for HCV subgenomic RNA replication. 293 cells were generally not permissive for replication of Huh-7...

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PMID: 14671129
DOI: 10.1128/jvi.78.1.491-501.2004

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