Article
p53 gene mutations in neoplastic transformation of C3H 10T1/2 and severe combined immunodeficiency fibroblasts.
Mutation research - 14 May 1999
Lang S, Marchesani M, Servomaa K, Kauppinen L, Jänne J, Rytömaa T, Wells R, Lun M, Elkind M M
Abstract excerpt
The relevance of p53 mutations to the neoplastic malignant transformation of rodent fibroblasts by genotoxic physical and chemical agents is not clear. In the present study, we investigated p53 mutations (in exons 5-8) in non-transformed and neoplastically transformed C3H 10T1/2 and severe combined immunodeficiency (SCID) cells. No p53 mutations were detected in 15 neoplastically transformed (two spontaneous, one...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- DNA
- DNA Mutational Analysis
- Genes, Tumor Suppressor
- Genes, p53
- Mice
- Mice, Inbred C3H
- Mice, SCID
- Mutation