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Article

p53 mutations in C57BL/6J murine thymic lymphomas induced by gamma-irradiation and N-methylnitrosourea.

Cancer research - 1 Jul 1992

Brathwaite O, Bayona W, Newcomb E W

Abstract excerpt

Genomic DNA from thymus tissue obtained from 47 C57BL/6J animals treated with the DNA alkylating agent N-methylnitrosourea or gamma-irradiation were screened for the presence of p53 mutations by using the single strand conformation polymorphism assay. Mutations were detected in 13% (4 of 30) of primary thymic lymphomas but none of 17 early stage lymphomas. The frequency of p53 mutations was the same in tumors...

Topics

Animals
Female
Gamma Rays
Genes, p53
Genes, ras
Lymphoma
Methylnitrosourea
Mice
Mice, Inbred C57BL
Mutation
Thymus Neoplasms
Trisomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1617648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1617648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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